Fenoldopam (mesylate)

产品编号: DC9424 Featured
Fenoldopam (mesylate)
结构式
67227-57-0
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中国地区超过5000个高品质化合物库存
应用领域
Fenoldopam(SKF 82526)甲磺酸盐是多巴胺受体D1选择性激动剂。
Cas No.: 67227-57-0
名称:
别名: Fenoldopam methanesulfonate;Corlopam mesylate;SKF-82526 mesylate
SMILES: OC1=C(OS(C)(=O)=O)C(Cl)=C2CCNCC(C3=CC=C(O)C=C3)C2=C1
分子式: C17H20ClNO6S
分子量: 401.8618
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Fenoldopam(SKF 82526) mesylate is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist. Fenoldopam is a selective dopamine-1 (DA1) agonist with natriuretic/diuretic properties. Fenoldopam stimulated cAMP accumulation in LLC-PK1 cells in a dose-dependent manner, an effect which could be blocked by the DA1-selective antagonist Sch 23390. Although fenoldopam was more potent than DA (EC50 55.5 +/- 7.75 nM vs. 1.65 +/- 0.64 microM) in stimulating cAMP accumulation in LLC-PK1 cells, the maximum stimulation obtained by fenoldopam was only 37% of the maximum stimulation obtained by DA(Emax 13.0 +/- 2.95 pmol/mg of protein vs. 35.6 +/- 10.19 pmol/mg of protein). Fenoldopam is a selective dopamine1 (DA1) receptor agonist. Most of the DA1 receptor agonist activity of fenoldopam resides in the R-enantiomer, which also shows weaker alpha 2-adrenoceptor antagonist activity Fenoldopam produces vasodilation in vascular beds that are rich in vascular DA1 receptors.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_2650_DC9424_67227-57-0
COA
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