iCRT 14

产品编号: DC9639 Featured
iCRT 14
结构式
677331-12-3
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中国地区超过5000个高品质化合物库存
应用领域
iCRT 14 是一种 β-连环蛋白应答转录(CRT)抑制剂,能够抑制 Wnt 信号通路,IC50 值为 40.3 nM。
Cas No.: 677331-12-3
名称:
别名: iCRT14;iCRT-14
SMILES: O=C(S/1)N(C2=CC=CC=C2)C(C1=CC3=C(C)N(C(C)=C3)C4=CN=CC=C4)=O
分子式: C21H17N3O2S
分子量: 375.4436
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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