SB-505124

产品编号: DC7278 Featured
SB-505124
结构式
694433-59-5
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中国地区超过5000个高品质化合物库存
应用领域
SB-505124 是一种选择性的 TGF-β Receptor type I receptor (ALK4,ALK5,ALK7) 抑制剂,对 LK4,ALK5 的 IC50 值分别为 129 nM 和 47 nM,对 ALK1,2,3 或 6 无作用。
Cas No.: 694433-59-5
名称: 2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine
别名: SB 505124; SB505124
SMILES: C(C1NC(C(C)(C)C)=NC=1C1C=C2C(=CC=1)OCO2)1=NC(C)=CC=C1
分子式: C20H21N3O2
分子量: 335.39964
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: SB505124 is identified as a reversible ATP competitive and selective ALK inhibitor of ALK4 and ALK5. SB505124 shows no toxicity to renal epithelial A498 cells at concentrations up to 100 μM For 48 hours, and blocks TGF-β–induced apoptosis of FaO cells an
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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