首页 > 产品 > Novel inhibitors

TAS-102

产品编号: DC10369
TAS-102
结构式
733030-01-8
此产品仅供科研所需，我们不出售给病人
​我们将匹配市场上最好的价格给您
Email：order@dcbio.cn
免费咨询电话：4008862077
询盘
我们的合作伙伴:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
中国地区超过5000个高品质化合物库存
应用领域
TAS-102 is a novel oral combination drug that consists of an antineoplastic thymidine-based nucleoside analog, trifluorothymidine, and a potent thymidine phosphorylase inhibitor, tipiracil, in a 1:0.5 molar ratio.
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 733030-01-8
名称:
别名: Trifluridine-tipiracil hydrochloride mixture
SMILES: O=C1N([C@H]2C[C@H](O)[C@@H](CO)O2)C=C(C(F)(F)F)C(N1)=O.O=C3NC(CN4CCCC4=N)=C(Cl)C(C3)=N.N.Cl
分子式: C10H11F3N2O5.1/2C9H11ClN4O2.1/2HCl
分子量: 435.76
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: TAS-102, a novel antimetabolite combination chemotherapy agent, consists of a rediscovered antimetabolite agent, trifluorothymidine (trifluridine, FTD) combined with the metabolic inhibitor of thymidine phosphorylase, tipiracil (TPI), in a 1:0.5 molar ratio. FTD is the active antitumor component of TAS-102; its monophosphate form inhibits thymidylate synthase, and its triphosphate form is incorporated into DNA in tumor cells. The incorporation into DNA is known to have antitumor effects, since the inhibition of thymidylate synthase caused by oral FTD rapidly disappears after the drug's elimination. When FTD is administered orally, it is rapidly degraded to its inactive form by thymidine phosphorylase in the intestines and liver (first-pass effect). Consequently, TPI is synthesized to maintain adequate plasma concentrations of orally-administered FTD and to potentiate the antitumor activity of FTD.TAS-102 and CPT-11 is a promising treatment option for colorectal or gastric cancer. TAS-102 monotherapy has a significant antitumor activity against KM12C/5-FUFU-bearing nude mice. The combination-treated (CPT-11-and TAS-102) group is significantly superior to monotherapy. FTD systemic exposure in plasma increaseS dose-dependently. The tumor growth rate and body weight gain decreaseS dose-dependently, but FTD concentrations in the DNA of tumor tissues and white blood cells increases dose-dependently. FTD inhibits colony formation of bone marrow cells in a concentration-dependent manner.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
TITLE DOWNLOAD
MSDS_3335_DC10369_733030-01-8
COA
LOT NO. DOWNLOAD
产品编号 产品名称 应用领域
DC9692 Volitinib(Savolitinib) Savolitinib(Volitinib; AZD-6094; Volitinib) is an orally bioavailable inhibitor of the c-Met receptor tyrosine kinase(IC50= 5 nM) with potential antineoplastic activity.
DC9574 A-317491 (sodium salt hydrate) A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors.
DC9545 Miglustat (hydrochloride) Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).
DC9542 MPTP (hydrochloride) MPTP HCl induced reduction in the DOPAC HVA/dopamine (DA) ratio and increase in striatal ascorbate (AS) oxidation in rats
DC9536 Sertindole Sertindole, a neuroleptic, is one of the newer antipsychotic medications available.
DC9505 Pifithrin-α (hydrobromide) Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.
DC9459 SB 415286 SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM.
DC9442 PF-04457845 PF-04457845 is a potent and exquisitely selective inhibitor of FAAH, with an IC50 of 7.2 nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen.
DC9402 Letermovir AIC246 is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.
DC9388 RS 504393 RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively).
​ 免费咨询电话：4008862077
​ QQ：1026657369
​ 邮箱：order@dcbio.cn
我们所有的产品仅供研究所需，严禁用于人体和其他目的
站点地图|隐私政策Copyright © 2018-2020 All Rights Reserved. 技术支持:库价软件