NSC348884

产品编号: DC9641 Featured
NSC348884
结构式
81624-55-7
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中国地区超过5000个高品质化合物库存
应用领域
NSC348884是核磷蛋白抑制剂, 破坏低聚物形成和诱导细胞凋亡,抑制不同癌细胞系增殖, IC50为1.7-4.0 μM。
Cas No.: 81624-55-7
名称: N,N,N',N' - tetrakis[(6 - methyl - 1H - benzimidazol - 2 - yl)methyl]ethane - 1,2 - diamine
别名: NSC348884,NSC-348884,NSC 348884
SMILES: CC1=CC2=C(C=C1)N=C(N2)CN(CCN(CC3=NC4=C(N3)C=C(C=C4)C)CC5=NC6=C(N5)C=C(C=C6)C)CC7=NC8=C(N7)C=C(C=C8)C
分子式: C38H40N10
分子量: 636.79
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: NSC348884 is a nucleolar phosphoprotein that displays several biological activities in ribosome biogenesis, cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, and centrosome duplication. NSC 348884 is a putative inhibitor of nucleophosmin (nucleolar phosphoprotein B23). NSC 348884 inhibits NPM oligomer formation, up-regulates p53 and induces apoptosis.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_2684_DC9641_81624-55-7
COA
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