CTEP

产品编号: DC7110 Featured
CTEP
结构式
871362-31-1
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中国地区超过5000个高品质化合物库存
应用领域
CTEP (RO 4956371) 是一种新颖的,长效的,可口服的 mGlu5 受体别构拮抗剂,IC50 值为 2.2 nM,对其选择性是对其他 mGlu 受体的 1000 多倍。
Cas No.: 871362-31-1
名称: Pyridine,2-chloro-4-[2-[2,5-dimethyl-1-[4-(trifluoromethoxy)phenyl]-1H-imidazol-4-yl]ethynyl]-
别名: mGluR5 inhibitor
SMILES: CC1=C(N=C(N1C2=CC=C(C=C2)OC(F)(F)F)C)C#CC3=CC(=NC=C3)Cl
分子式: C19H13ClF3N3O
分子量: 391.77423
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: CTEP inhibits quisqualate-induced Ca2+ mobilization with an IC50 of 11.4 nM and [3H]IP accumulation with an IC50 of 6.4 nM in HEK293 cells stably expressing human mGlu5. CTEP inhibits the constitutive activity of human mGlu5 by approximately 50% with an I
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_1559_DC7110_871362-31-1
COA
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