SBI-115

产品编号: DC24210 Featured
SBI-115
结构式
882366-16-7
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中国地区超过5000个高品质化合物库存
应用领域
SBI-115 是一种 TGR5 (GPCR19) 拮抗剂。SBI-115 通过抑制 TGR5 降低多囊性肝病的肝囊肿形成。
Cas No.: 882366-16-7
名称: 4-Pyrimidinecarboxylic acid, 5-chloro-2-(ethylsulfonyl)-, 3-methylphenyl ester
别名: SBI-115; SBI 115; SBI115
SMILES: O=C(C1=NC(S(=O)(CC)=O)=NC=C1Cl)OC2=CC=CC(C)=C2
分子式: C14H13ClN2O4S
分子量: 340.02
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5. TGR5 contributes to hepatic cystogenesis by increasing cAMP and enhancing cholangiocyte proliferation; our data suggest that a TGR5 antagonist alone or concurrently with somatostatin receptor agonists represents a potential therapeutic approach in polycystic liver disease
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_1254_DC24210_882366-16-7
COA
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