XL147 analogue(PI3K inhibitor X)

产品编号: DC1068 Featured
XL147 analogue(PI3K inhibitor X)
结构式
956958-53-5
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中国地区超过5000个高品质化合物库存
应用领域
Pilaralisib analogue (XL147 analogue) 是一种代表性的选择性 PI3Kα 抑制剂,详细信息请参考专利文献 WO2012006552A1 中 Table 1 中的化合物 147。
Cas No.: 956958-53-5
名称: N-(3-(benzo[c][1,2,5]thiadiazol-5-ylamino)quinoxalin-2-yl)-4-methylbenzenesulfonamide
别名: XL-147,XL 147
SMILES: C(S(NC1C(NC2C=CC3C(C=2)=NSN=3)=NC2C(N=1)=CC=CC=2)(=O)=O)1=CC=C(C)C=C1
分子式: C21H16N6O2S2
分子量: 448.52
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: XL147 analogue is a Class 1 PI3K kinase family inhibitor, and is an orally bioavailable small molecule, targeting the class I phosphatidylinositol 3 kinase (PI3K) family of lipid kinases, with potential antineoplastic activity. Class 1 PI3K kinase family inhibitor XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K signaling pathway; this may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents including genotoxic agents and receptor tyrosine kinase inhibitors. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information about the solubility of XL147 (SAR245408) in water, the solubility of XL147 (SAR245408) in DMSO, the solubility of XL147 (SAR245408) in PBS buffer, the animal experiment(test) of XL147 (SAR245408),the in vivo,in vitro and clinical trial test of XL147 (SAR245408),the cell experiment(test) of XL147 (SAR245408),the IC50, EC50 and Affinity of XL147 (SAR245408), please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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