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产品编号 产品名称 CAS No.
DC10630 ONO-7300243

ONO-7300243 is a novel, potent LPA1(Lysophosphatidic Acid Receptor) antagonist with an IC50 of 160 nM.

638132-34-0
DC1071 Vemurafenib (PLX4032)

PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM.

918504-65-1
DC11329 Fadrozole (hydrochloride)

Fadrozole is a non-steroidal aromatase inhibitor (IC50s = 5 and 1.4 nM for human placental and rat ovarian microsomal aromatase, respectively).

102676-31-3
DC11367 PF-04447943

PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis.

1082744-20-4
DC12285 CID 1375606

CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27.

313493-80-0
DC12703 5-Formyl-2-pyrimidinecarbonitrile

5-Formyl-2-pyrimidinecarbonitrile is a chemical intermidate..

1001755-57-2
DC20016 Naloxegol

Naloxegol is a CYP3A4 enzyme inhibitor, is a peripherally-selective opioid antagonist, for the treatment of opioid-induced constipation.

854601-70-0
DC20018 Enocyanin

Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity.

11029-12-2
DC2013 Bafetinib (INNO-406)

Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM and 19 nM, respectively.

859212-16-1
DC2047 Crizotinib (PF-2341066)

PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nnM, respectivley.

877399-52-5
DC2056 Droxidopa (L-DOPS,SM-5688)

Droxidopa (L-DOPS) is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).

23651-95-8
DC2070 pan-Akt inhibitor GS690693

GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively.

937174-76-0
DC20928 CRT0066101

A potent, specific, orally active pan-PKD (protein kinase D) inhibitor with biochemical IC50 of 1, 2.5 and 2 nM for PKD1, 2, and 3 respectively.

1883545-60-5
DC2105 Lovastatin (MK-803)

Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM, used for lowering cholesterol (hypolipidemic agent).

75330-75-5
DC21485 PF-05089771

PF-05089771 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 11 nM, >1,000-fold selectivity over Nav1.3, 1.4 and Nav1.5, 1.8.

1430806-04-4
DC22537 SMAP

SMAP (DT-061, DT061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth.

1809427-18-6
DC22612 Afatinib

An irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively.

850140-72-6
DC22625 Rolipram

A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

61413-54-5
DC23204 WZ8040

WZ8040 is a potent, mutant-selective, irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I) and is 100-fold less potent against wild-type EGFR.

1214265-57-2
DC24050 Anamorelin hydrochloride

A non-peptide, centrally-penetrant and selective agonist of GHSR with appetite-enhancing and anabolic effects.

861998-00-7
DC24145 G-418 disulfate

An aminoglycoside antibiotic similar in structure to gentamicin B1.

108321-42-2
DC3105 BMS-599626 (AC480)

BMS-599626 (AC480) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, respectively.

714971-09-2
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