产品编号 | 产品名称 | CAS No. |
DC10630 |
ONO-7300243
ONO-7300243 is a novel, potent LPA1(Lysophosphatidic Acid Receptor) antagonist with an IC50 of 160 nM. |
638132-34-0 |
DC1071 |
Vemurafenib (PLX4032)
PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM. |
918504-65-1 |
DC11329 |
Fadrozole (hydrochloride)
Fadrozole is a non-steroidal aromatase inhibitor (IC50s = 5 and 1.4 nM for human placental and rat ovarian microsomal aromatase, respectively). |
102676-31-3 |
DC11367 |
PF-04447943
PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis. |
1082744-20-4 |
DC12285 |
CID 1375606
CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27. |
313493-80-0 |
DC12703 |
5-Formyl-2-pyrimidinecarbonitrile
5-Formyl-2-pyrimidinecarbonitrile is a chemical intermidate.. |
1001755-57-2 |
DC20016 |
Naloxegol
Naloxegol is a CYP3A4 enzyme inhibitor, is a peripherally-selective opioid antagonist, for the treatment of opioid-induced constipation. |
854601-70-0 |
DC20018 |
Enocyanin
Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity. |
11029-12-2 |
DC2013 |
Bafetinib (INNO-406)
Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM and 19 nM, respectively. |
859212-16-1 |
DC2047 |
Crizotinib (PF-2341066)
PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nnM, respectivley. |
877399-52-5 |
DC2056 |
Droxidopa (L-DOPS,SM-5688)
Droxidopa (L-DOPS) is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). |
23651-95-8 |
DC2070 |
pan-Akt inhibitor GS690693
GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively. |
937174-76-0 |
DC20928 |
CRT0066101
A potent, specific, orally active pan-PKD (protein kinase D) inhibitor with biochemical IC50 of 1, 2.5 and 2 nM for PKD1, 2, and 3 respectively. |
1883545-60-5 |
DC2105 |
Lovastatin (MK-803)
Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM, used for lowering cholesterol (hypolipidemic agent). |
75330-75-5 |
DC21485 |
PF-05089771
PF-05089771 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 11 nM, >1,000-fold selectivity over Nav1.3, 1.4 and Nav1.5, 1.8. |
1430806-04-4 |
DC22537 |
SMAP
SMAP (DT-061, DT061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth. |
1809427-18-6 |
DC22612 |
Afatinib
An irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively. |
850140-72-6 |
DC22625 |
Rolipram
A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. |
61413-54-5 |
DC23204 |
WZ8040
WZ8040 is a potent, mutant-selective, irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I) and is 100-fold less potent against wild-type EGFR. |
1214265-57-2 |
DC24050 |
Anamorelin hydrochloride
A non-peptide, centrally-penetrant and selective agonist of GHSR with appetite-enhancing and anabolic effects. |
861998-00-7 |
DC24145 |
G-418 disulfate
An aminoglycoside antibiotic similar in structure to gentamicin B1. |
108321-42-2 |
DC3105 |
BMS-599626 (AC480)
BMS-599626 (AC480) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, respectively. |
714971-09-2 |