BMS754807
产品编号: DC3126
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应用领域
BMS-754807 是有效、可逆的胰岛素样生长因子1受体/胰岛素受体抑制剂，其 IC50 值分别为 1.8 和 1.7 nM，Ki 值均小于 2 nM；同时也抑制 Met，RON，TrkA，TrkB，AurA 和 AurB 的活性，其IC50 值分别为 6，44，7，4，9和 25 nM。
| Cas No.: |
1001350-96-4 |
| 名称: |
(S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide |
| 别名: |
BMS-754807,BMS 754807 |
| SMILES: |
N(C1N=C(NC2C=C(C3CC3)NN=2)C2=CC=CN2N=1)1CCC[C@]1(C)C(NC1=CC=C(F)N=C1)=O |
| 分子式: |
C23H24FN9O |
| 分子量: |
461.49 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity. IGF-1R antagonist BMS-7548077 binds to IGF-1R, preventing IGF-1 ligand binding and activation of IGF-1R-me |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_1330_DC3126_1001350-96-4 |
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COA
| LOT NO. |
DOWNLOAD |
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