| Cas No.: | 1011244-68-0 |
| 名称: | N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide |
| 别名: | |
| SMILES: | C1=CC(=CC=C1C(=O)NC2=NC=C(C=C2)N)C(F)(F)F |
| 分子式: | C13H10F3N3O |
| 分子量: | 281.23 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
| In Vivo: | |
| In Vitro: | |
| References: | TFAP is a cell-permeable pyridinyl-benzamide compound that acts as a Cox-1 (IC50 of 0.80 μM) selective inhibitor versus Cox-2 (IC50 of 210 μM) by targeting the enzyme's active site and displays analgesic properties in mice and rats in vivo (30 mg/kg, p.o.) without long-term cytotoxic effects (300 mg/kg in mice, daily, p.o. for 14 days). Unlike Cox-2-inhibiting analgesics such as aspirin, TFAP is shown not to cause gastric damage in rats in vivo (300 mg/kg, p.o.). |
| Kinase Assay: | |
| Cell Assay: | |
| Animal Administration: | |
| References: |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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