MK-2206 2HCl
产品编号: DC7465
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应用领域
MK-2206 dihydrochloride (MK-2206 (2HCl)) 是一种口服有效的 Akt 变构抑制剂，抑制 Akt1/Akt2/Akt3 的 IC50 分别为 5 nM/12 nM/65 nM。MK-2206 dihydrochloride 可以诱导自噬 (autophagy) 作用。
| Cas No.: |
1032350-13-2 |
| 名称: |
8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one |
| 别名: |
MK 2206 2HCl,MK2206 2HCl |
| SMILES: |
N1C2=C(C3=NNC(=O)N3C=C2)C=C(C2=CC=CC=C2)C=1C1=CC=C(C(N)2CCC2)C=C1 |
| 分子式: |
C25H21N5O.2HCl |
| 分子量: |
480.39 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, P |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_1777_DC7465_1032350-13-2 |
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COA
| LOT NO. |
DOWNLOAD |
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询盘
