Apitolisib(GDC-0980)
产品编号: DC5081
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应用领域
Apitolisib (GDC-0980; GNE 390; RG 7422) 是一种口服有效的 PI3K 和 mTOR (TORC1/2) 激酶抑制剂，抑制 PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ 的活性，IC50 值为 5 nM/27 nM/7 nM/14 nM。 抑制mTOR，Ki 为 17 nM。
| Cas No.: |
1032754-93-0 |
| 名称: |
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| 别名: |
GDC-0980; RG7422; RG-7422; GDC 0980; GNE 390，GDC0980. |
| SMILES: |
CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)[C@H](C)O |
| 分子式: |
C23H30N8O3S |
| 分子量: |
498.6 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
GDC-0980 is a dual PI3 kinase/mTOR inhibitor, is also an orally available agent targeting phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_1432_DC5081_1032754-93-0 |
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COA
| LOT NO. |
DOWNLOAD |
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询盘
