ALZ-801

产品编号: DC11301 Featured
ALZ-801
结构式
1034190-08-3
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中国地区超过5000个高品质化合物库存
应用领域
ALZ-801 是一种口服可用的小分子 β-淀粉样蛋白 β-amyloid (Aβ) 抑制剂, Tramiprosate 缬氨酸偶联前药,有显着改善的 PK 特性和胃肠耐受性。ALZ-801 有潜力用于治疗阿尔茨海默病的研究。
Cas No.: 1034190-08-3
名称: (S)-3-(2-aMino-3-MethylbutanaMido)propane-1-sulfonic acid
别名: ALZ-801,ALZ801,ALZ 801
SMILES: C(S(O)(=O)=O)CCNC(=O)[C@H](N)C(C)C
分子式: C8H18N2O4S
分子量: 238.302
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: ALZ-801 is an orally available, valine-conjugated prodrug of tramiprosate. Tramiprosate, the active agent, is a small-molecule b-amyloid (Ab) anti-oligomer and aggregation inhibitor that was evaluated extensively in preclinical and clinical investigations for the treatment of Alzheimer’s disease (AD). Tramiprosate has been found to inhibit b-amyloid oligomer formation by a multi-ligand enveloping mechanism of action that stabilizes Ab42 monomers, resulting in the inhibition of formation of oligomers and subsequent aggregation. Although promising as an AD treatment, tramiprosate exhibited two limiting deficiencies: high intersubject pharmacokinetic (PK) variability likely due to extensive gastrointestinal metabolism, and mild-to-moderate incidence of nausea and vomiting. To address these, we developed an optimized prodrug, ALZ-801, which retains the favorable efficacy attributes of tramiprosate while improving oral PK variability and gastrointestinal tolerability. In this study, we summarize the phase I bridging program to evaluate the safety, tolerability and PK for ALZ-801 after single and multiple rising dose administration in healthy volunteers.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
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产品编号 产品名称 应用领域
DC11301 ALZ-801 ALZ-801 是一种口服可用的小分子 β-淀粉样蛋白 β-amyloid (Aβ) 抑制剂, Tramiprosate 缬氨酸偶联前药,有显着改善的 PK 特性和胃肠耐受性。ALZ-801 有潜力用于治疗阿尔茨海默病的研究。
DC10506 CPHPC(Miridesap) Miridesap 是血清淀粉样蛋白 P 组分 (SAP) 的配体,能抑制和解离 SAP 与淀粉状蛋白原纤维的结合。