Afuresertib HCl
产品编号: DC7994
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应用领域
Afuresertib hydrochloride (GSK 2110183 hydrochloride) 是一个口服有效的，ATP 竞争性的选择性 pan-Akt 抑制剂，作用于 Akt1/Akt2/Akt3，Ki 值分别为 0.08/2/2.6 nM。
| Cas No.: |
1047645-82-8 |
| 名称: |
N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride |
| 别名: |
Afuresertib |
| SMILES: |
C(C(N[C@H](CC1=CC=CC(F)=C1)CN)=O)1SC(Cl)=C(C2N(C)N=CC=2Cl)C=1.[H]Cl |
| 分子式: |
C18H18Cl3FN4Os |
| 分子量: |
463.78 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
Afuresertib (GSK2110183) is a potent pan-AKT inhibitor that demonstrated synergy with bortezomib in preclinical models of multiple myeloma (MM). For the detailed information of Afuresertib (GSK-2110183), the solubility of Afuresertib (GSK-2110183) in wate |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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