Defactinib (VS-6063, PF-04554878)
产品编号: DC7695
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应用领域
Defactinib (VS-6063; PF-04554878) 是一种新型 FAK 抑制剂，抑制 FAK 在 Tyr397 位点磷酸化，这种作用具有时间和剂量依赖性。
| Cas No.: |
1073154-85-4 |
| 名称: |
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| 别名: |
VS-6063; VS6063; VS 6063; PF04554878; PF-04554878; PF 04554878 |
| SMILES: |
CNC(=O)C1=CC=C(C=C1)NC2=NC=C(C(=N2)NCC3=NC=CN=C3N(C)S(=O)(=O)C)C(F)(F)F |
| 分子式: |
C20H21F3N8O3S |
| 分子量: |
510.5 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
Defactinib is a potent, selective, and orally active FAK inhibitor with demonstrated tolerability and preliminary clinical activity working as a single agent as well as in combination with paclitaxel.Defactinib inhibited FAK phosphorylation at the Tyr397 |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_1908_DC7695_1073154-85-4 |
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COA
| LOT NO. |
DOWNLOAD |
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