LY2510924

产品编号: DC10782 Featured
LY2510924
结构式
1088715-84-7
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中国地区超过5000个高品质化合物库存
应用领域
LY2510924是有效,选择性的 CXCR4 拮抗剂;阻止SDF-1结合CXCR4,IC50值为0.079 nM。
Cas No.: 1088715-84-7
名称: (2S,5S,20R)-N-((S)-1-amino-6-(isopropylamino)-1-oxohexan-2-yl)-2-benzyl-5-(4-hydroxybenzyl)-8-(4-(isopropylamino)butyl)-14-(naphthalen-2-ylmethyl)-3,6,9,12,15,18,23-heptaoxo-11-(3-ureidopropyl)-1,4,7,10,13,16,19-heptaazacyclotricosane-20-carboxamide
别名: LY2510924; LY-2510924; LY 2510924
SMILES: O=C(NCC(N[C@@H](C(N[C@@H](CCCCNC(C)C)C(N)=O)=O)CCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=C(O)C=C2)C3=O)=O)=O)=O)C(CC4=CC=C(C=CC=C5)C5=C4)NC(C(CCCNC(N)=O)NC(C(N3)CCCCNC(C)C)=O)=O
分子式: C62H87N13O11
分子量: 1189.66
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: LY2510924 is an inhibitor of CXC chemokine receptor 4 (CXCR4), with potential antineoplastic activity. Upon subcutaneous administration, CXCR4 inhibitor LY2510924 binds to the chemokine receptor CXCR4, thereby preventing CXCR4 binding to its ligand, stromal derived factor-1 (SDF-1), and subsequent receptor activation. This may result in decreased tumor cell proliferation and migration. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC10782 LY2510924 LY2510924是有效,选择性的 CXCR4 拮抗剂;阻止SDF-1结合CXCR4,IC50值为0.079 nM。