NVP-BSK805 dihydrochloride
产品编号: DC7216
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应用领域
NVP-BSK805 is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM; >20-fold selectivity towards JAK1, JAK3 and TYK2.
| Cas No.: |
1092499-93-8 |
| 名称: |
8-(3,5-difluoro-4-(morpholinomethyl)phenyl)-2-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxaline |
| 别名: |
BSK 805; BSK-805; BSK805; NVP-BSK 805 |
| SMILES: |
FC1=C(CN2CCOCC2)C(F)=CC(C3=C4N=C(C5=CN(C6CCNCC6)N=C5)C=NC4=CC=C3)=C1 |
| 分子式: |
C27H28F2N6O.2HCl |
| 分子量: |
563.47 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
NVP-BSK805 is found to potently inhibit JAK2, whereas displaying more than 20-fold selectivity towards JAK1, JAK3, and TYK2. NVP-BSK805 causes half-maximal inhibition of full-length JAK2V617F and JAK2 wild-type enzymes at 0.5 nM. NVP-BSK805 blocks the gro |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_3416_DC7216_1092499-93-8 |
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COA
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