CX-5461
产品编号: DC7810
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应用领域
CX-5461是一种有效，口服的rRNA合成抑制剂。 它在HCT-116，A375和MIA PaCa-2细胞中抑制RNA聚合酶I驱动的rRNA转录，IC50为142，113和54 nM。
| Cas No.: |
1138549-36-6 |
| 名称: |
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| 别名: |
CX-5461,CX5461,CX 5461 |
| SMILES: |
N12C3=CC=CC=C3SC1=C(C(NCC1=NC=C(C)N=C1)=O)C(=O)C1=C2N=C(N2CCCN(C)CC2)C=C1 |
| 分子式: |
C27H27N7O2S |
| 分子量: |
513.61 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
CX-5461 is found to selectively inhibit rRNA synthesis (Pol I IC50=142 nM; Pol II IC50 > 25 μM; selectivity ~200-fold) in the HCT-116 cells. Selective inhibition of rRNA synthesis by CX-5461 is confirmed in two other human solid tumor cell lines; melanoma |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
