AMG337
产品编号: DC8845
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应用领域
AMG-337是一种有效的高度选择性的ATP竞争性MET激酶抑制剂, IC50 < 5 nM。
| Cas No.: |
1173699-31-4 |
| 名称: |
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| 别名: |
AMG 337,AMG-337 |
| SMILES: |
CC(C1=NN=C2N1C=C(C=C2F)C3=CN(N=C3)C)N4C=CC5=NC=C(C=C5C4=C)OCCOC |
| 分子式: |
C23H22FN7O3 |
| 分子量: |
463.46 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays.in vitro: AMG-337 demonstrates exquisite selectivity for MET when profiled against a diverse panel of over 400 protein and lipid kinases in a competitive binding assay. In cellular assays, AMG 337 inhibits HGF-dependent MET phosphorylation with an IC50 of < 10 nM. AMG 337 is a selective inhibitor of Met, which inhibits multiple mechanisms of Met activation.
in vivo: AMG-337 demonstrates robust activity in MET-dependent cancer models. Oral administration of AMG 337 results in robust dose-dependent anti-tumor efficacy in MET amplified gastric cancer xenograft models, with inhibition of tumor growth consistent with the pharmacodynamic modulation of MET signaling. |
| Kinase Assay: |
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| Animal Administration: |
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| References: |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_2535_DC8845_1173699-31-4 |
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COA
| LOT NO. |
DOWNLOAD |
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