AMG337

产品编号: DC8845 Featured
AMG337
结构式
1173699-31-4
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中国地区超过5000个高品质化合物库存
应用领域
AMG-337是一种有效的高度选择性的ATP竞争性MET激酶抑制剂, IC50 < 5 nM。
Cas No.: 1173699-31-4
名称:
别名: AMG 337,AMG-337
SMILES: CC(C1=NN=C2N1C=C(C=C2F)C3=CN(N=C3)C)N4C=CC5=NC=C(C=C5C4=C)OCCOC
分子式: C23H22FN7O3
分子量: 463.46
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays.in vitro: AMG-337 demonstrates exquisite selectivity for MET when profiled against a diverse panel of over 400 protein and lipid kinases in a competitive binding assay. In cellular assays, AMG 337 inhibits HGF-dependent MET phosphorylation with an IC50 of < 10 nM. AMG 337 is a selective inhibitor of Met, which inhibits multiple mechanisms of Met activation. in vivo: AMG-337 demonstrates robust activity in MET-dependent cancer models. Oral administration of AMG 337 results in robust dose-dependent anti-tumor efficacy in MET amplified gastric cancer xenograft models, with inhibition of tumor growth consistent with the pharmacodynamic modulation of MET signaling.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_2535_DC8845_1173699-31-4
COA
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产品编号 产品名称 应用领域
DC8845 AMG337 AMG-337是一种有效的高度选择性的ATP竞争性MET激酶抑制剂, IC50 < 5 nM。