BI 409306
产品编号: DC11389
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中国地区超过5000个高品质化合物库存
应用领域
BI-409306 是一种有效的，选择性的 PDE9A 抑制剂，IC50 值为 52 nM，对其他 PDE 的活性较弱，包括 PDE1A (IC50，1.4 µM)，PDE1C (IC50，1.0 µM)，PDE2A，PDE3A，PDE4B，PDE5A，PDE6AB，PDE7A 和 PDE10A (IC50 > 10 μM)；BI-409306 可用于中枢神经系统障碍疾病中提高记忆力的研究。
| Cas No.: |
118967-28-9 |
| 名称: |
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| 别名: |
BI 409306,BI-409306，BI409306 |
| SMILES: |
C1=CC=NC(CC2=NC3N(C4CCOCC4)N=CC=3C(=O)N2)=C1 |
| 分子式: |
C16H17N5O2 |
| 分子量: |
311.14 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
BI 409306 is an inhibitor of phosphodisterase 9A（PDE9A）.PDE9A is a drug target for cognitive decline in Alzheimer's and other diseases because this enzyme reduces brain levels of the second messenger cyclic guanosine monophosphate. cGMP transduces signals by the neurotransmitters nitric oxide and glutamate. This pathway modulates synaptic transmission and plasticity in the hippocampus and cerebral cortex, and is reduced in AD brain (Zhihui 2013). |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
