URMC-099
产品编号: DC7889
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应用领域
URMC-099 是一种口服生物有效的混合谱系激酶 3 (MLK3) (IC50=14 nM) 抑制剂，具有优异的血脑屏障穿透性。
| Cas No.: |
1229582-33-5 |
| 名称: |
3-(1H-indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine |
| 别名: |
URMC-099,URMC 099 |
| SMILES: |
CN1CCN(CC1)CC2=CC=C(C=C2)C3=CN=C4C(=C3)C(=CN4)C5=CC6=C(C=C5)NC=C6 |
| 分子式: |
C27H27N5 |
| 分子量: |
421.54 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
URMC-099 inhibits LPS-induced TNFα release in microglial cells, and HIV-1 Tat-induced release of cytokines in human monocytes. URMC-099 prevents destruction and phagocytosis of cultured neuronal axons by microglia cells. URMC-099 reduces fMLP-induced ch |
| Kinase Assay: |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_2001_DC7889_1229582-33-5 |
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COA
| LOT NO. |
DOWNLOAD |
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询盘
