SGI-7079
产品编号: DC8535
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中国地区超过5000个高品质化合物库存
应用领域
SGI-7079是一种Axl抑制剂, 显著抑制 SUM149 和 KPL-4 细胞增殖, IC50 分别为0.43 和 0.16 μM。
| Cas No.: |
1239875-86-5 |
| 名称: |
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| 别名: |
SGI-7079,SGI 7079,SGI7079 |
| SMILES: |
CC1=CNC2=NC(=NC(=C12)C3=CC(=CC=C3)CC#N)NC4=CC(=C(C=C4)N5CCN(CC5)C)F |
| 分子式: |
C26H26FN7 |
| 分子量: |
455.53 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
SGI-7079 is a novel Axl inhibitor. SGI-7079 decreased IBC cell proliferation, migration and invasion in vitro and inhibited tumor growth of IBC cells in vivo. Mesenchymal cells also expressed increased levels of the receptor tyrosine kinase Axl and showed a trend toward greater sensitivity to the Axl inhibitor SGI-7079, whereas the combination of SGI-7079 with erlotinib reversed erlotinib resistance in mesenchymal lines expressing Axl and in a xenograft model of mesenchymal NSCLC. |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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