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应用领域
LGK-974 is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM.
| Cas No.: |
1243244-14-5 |
| 名称: |
[2,4'-Bipyridine]-5-acetamide,2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]- |
| 别名: |
LGK974; LGK-974 |
| SMILES: |
O=C(NC1=NC=C(C2=NC=CN=C2)C=C1)CC3=CN=C(C4=CC(C)=NC=C4)C(C)=C3 |
| 分子式: |
C23H20N6O |
| 分子量: |
396.44 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
LGK974 effectively displaces [3H]-GNF-1331 with IC50 of 1 nM in the PORCN radioligand binding assay, and shows no major cytotoxicity in cells up to 20 µM. LGK974 shows comparable inhibitory activities against all tested Wnts with IC50 ranging from 0.05 to |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_3411_DC7186_1243244-14-5 |
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COA
| LOT NO. |
DOWNLOAD |
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