CLR1501

产品编号: DC9797 Featured
CLR1501
结构式
1250963-36-0
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中国地区超过5000个高品质化合物库存
应用领域
Difluoro[2-({hydroxy[(18-{4-[(1H-pyrrol-2-yl-κN)(2H-pyrrol-2-ylidene-κN)methyl]phenyl}octadecyl)oxy]phosphoryl}oxy)-N,N,N-trimethylethanaminiumato(2-)]boron
Cas No.: 1250963-36-0
名称: 18-(4-(5,5-difluoro-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-10-yl)phenyl)octadecyl (2-(trimethylammonio)ethyl) phosphat
别名:
SMILES: P(=O)(OCC[N+](C)(C)C)(OCCCCCCCCCCCCCCCCCCC1C=CC(C2C3N(C=CC=3)[B-](F)(F)[N+]3C=2C=CC=3)=CC=1)[O-]
分子式: C38H59BF2N3O4P
分子量: 701.43
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: CLR1501 is a synthetic analogs of the tumor-targeting agent alkylphosphocholine (APC), which is specifically attracted to cancer cells. CLR1501 is molecularly altered to carry fluorescent dyes that glow under lights with specific wavelength in the green (CLR1501) . Viewed under appropriate conditions, CLR1501 dye makes tumor cells "light up" so that it can be readily distinguished from neighboring normal brain tissue.The results confirmed that CLR150 was attracted to tumor cells, and emitted light of specific wavelengths under appropriate imaging conditions. Both APC analogs provided "excellent fluorescence discrimination of tumor from adjacent normal brain." Tumors could be clearly seen using different types of commercially available imaging systems. Imaging with CLR1501 green dye showed fluorescence similar to that achieved with currently used 5-ALA dye. The use of near-infrared fluorescence would offer additional advantages during actual surgery, compared to fluorescence in the visible-light range.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_2804_DC9797_1250963-36-0
COA
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