SCH 23390 hydrochloride

产品编号: DC10189 Featured
SCH 23390 hydrochloride
结构式
125941-87-9
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中国地区超过5000个高品质化合物库存
应用领域
SCH 23390 hydrochloride是有效的多巴胺受体D1拮抗剂,对D1和D5的Ki值分别为0.2和0.3 nM。
Cas No.: 125941-87-9
名称:
别名: SCH23390 hydrochloride; SCH-23390 hydrochloride; R-(+)-SCH23390 hydrochloride
SMILES: OC1=C(Cl)C=C2CCN(C)C[C@H](C3=CC=CC=C3)C2=C1.[H]Cl
分子式: C17H19Cl2NO
分子量: 324.24
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: The commercially available hydrochloride salt has a molecular weight of 324.25 and is a white solid soluble in water (8 mg/mL), DMSO (3 mg/mL), or ethanol (2 mg/mL). SCH 23390 also shows high affinity (Ki=9.3 nM) at h5-HT2C sites. SCH23390 blocks endogenous GIRK currents induced by either somatostatin or D3 dopamine receptors in AtT-20 cells (IC50=268 nM).SCH 23390 has been a major tool in gaining a better understanding of the role of the dopamine system. SCH 23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat. The repeated administration of SCH 23390 (0.05 mg/kg s.c., thrice daily for 21 days) enhances the steady-state density of dopamine D1 receptors in the striatum (+30%) and substantia nigra (+24%). This treatment also increases the production rates of dopamine D1 receptors in the striatum (+44%) and substantia nigra (+54%). Systemic SCH 23390 reduces saccharin seeking evidenced by a significant reduction in active lever responding and a significant reduction in the number of active lever-contingent deliveries of the tone + light cue following pretreatment with 10 μg/kg SCH 23390[5].
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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DC10189 SCH 23390 hydrochloride SCH 23390 hydrochloride是有效的多巴胺受体D1拮抗剂,对D1和D5的Ki值分别为0.2和0.3 nM。