MI-3 (Menin-MLL Inhibitor)

产品编号: DC8246 Featured
MI-3 (Menin-MLL Inhibitor)
结构式
1271738-59-0
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中国地区超过5000个高品质化合物库存
应用领域
MI-3 (Menin-MLL inhibitor 3) 是一种有效且高亲和力的 menin-MLL 抑制剂,IC50 值为 648 nM,Kd 值为 201 nM。
Cas No.: 1271738-59-0
名称: 4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)-thieno[2,3-d]pyrimidine
别名: MI3,MI 3
SMILES: C1=NC(N2CCN(C3=NCC(C)(C)S3)CC2)=C2C=C(C(C)C)SC2=N1
分子式: C18H25N5S2
分子量: 375.55
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: In HEK293 cells, MI-3 accesses the protein target and effectively inhibits the menin-MLL-AF9 interaction. MI-3 effectively blocks MLL fusion protein-mediated leukemic transformation by downregulating the expression of target genes required for MLL fusion protein oncogenic activity. In human MLL leukemia cell lines harboring different MLL translocations, MI-3 effectively blocks cell proliferation, and induces apoptosis. For the detailed information of MI-3 (Menin-MLL Inhibitor), the solubility of MI-3 (Menin-MLL Inhibitor) in water, the solubility of MI-3 (Menin-MLL Inhibitor) in DMSO, the solubility of MI-3 (Menin-MLL Inhibitor) in PBS buffer, the animal experiment (test) of MI-3 (Menin-MLL Inhibitor), the cell expriment (test) of MI-3 (Menin-MLL Inhibitor), the in vivo, in vitro and clinical trial test of MI-3 (Menin-MLL Inhibitor), the EC50, IC50,and affinity,of MI-3 (Menin-MLL Inhibitor), For the detailed information of MI-3 (Menin-MLL Inhibitor), the solubility of MI-3 (Menin-MLL Inhibitor) in water, the solubility of MI-3 (Menin-MLL Inhibitor) in DMSO, the solubility of MI-3 (Menin-MLL Inhibitor) in PBS buffer, the animal experiment (test) of MI-3 (Menin-MLL Inhibitor), the cell expriment (test) of MI-3 (Menin-MLL Inhibitor), the in vivo, in vitro and clinical trial test of MI-3 (Menin-MLL Inhibitor), the EC50, IC50,and affinity,of MI-3 (Menin-MLL Inhibitor), Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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