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Etelcalcetide Hydrochloride(AMG-416)

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Etelcalcetide Hydrochloride(AMG-416)
结构式
1334237-71-6
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中国地区超过5000个高品质化合物库存
应用领域
Etelcalcetide hydrochloride (AMG 416 hydrochloride) 是一种合成肽，有钙敏感受体 (CaSR) 活化剂的作用。Etelcalcetide hydrochloride 可有效降低接受血液透析的继发性甲状旁腺功能亢进患者的甲状旁腺激素 (PTH) 浓度。
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 1334237-71-6
名称: N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide disulfide with L-cysteine hydrochloride
别名: AMG 416, KAI-4169, velcalcetide hydrochloride,Parsabiv,AMG416, 1262780-97-1 (free base)
SMILES: C[C@@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC(C)=O)CSSC[C@H](N)C(O)=O)=O)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(N[C@@H](C(N)=O)CCCNC(N)=N)=O
分子式: C38H73N21O10S2.HCl
分子量: 1084.71
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Etelcalcetide, also known as AMG 416 and KAI-4169, is a D-amino peptide calcimimetic undergoing clinical evaluation for the treatment of secondary hyperparathyroidism for patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is administered intravenously at the end of each dialysis session. It functions by binding to and activating the calcium-sensing receptor (CaSR) in the parathyroid gland as an allosteric activator, resulting in PTH reduction and suppression. Elevated PTH is often observe in patients with CKD. On August 25, 2015 Amgen Inc. announced its submission of a New Drug Application to the Food and Drug Administration for etelcalcetide. For the detailed information of Etelcalcetide Hydrochloride(AMG 416), the solubility of Etelcalcetide Hydrochloride(AMG 416) in water, the solubility of Etelcalcetide Hydrochloride(AMG 416) in DMSO, the solubility of Etelcalcetide Hydrochloride(AMG 416) in PBS buffer, the animal experiment (test) of Etelcalcetide Hydrochloride(AMG 416), the cell expriment (test) of Etelcalcetide Hydrochloride(AMG 416), the in vivo, in vitro and clinical trial test of Etelcalcetide Hydrochloride(AMG 416), the EC50, IC50,and affinity,of Etelcalcetide Hydrochloride(AMG 416), For the detailed information of Etelcalcetide Hydrochloride(AMG 416), the solubility of Etelcalcetide Hydrochloride(AMG 416) in water, the solubility of Etelcalcetide Hydrochloride(AMG 416) in DMSO, the solubility of Etelcalcetide Hydrochloride(AMG 416) in PBS buffer, the animal experiment (test) of Etelcalcetide Hydrochloride(AMG 416), the cell expriment (test) of Etelcalcetide Hydrochloride(AMG 416), the in vivo, in vitro and clinical trial test of Etelcalcetide Hydrochloride(AMG 416), the EC50, IC50,and affinity,of Etelcalcetide Hydrochloride(AMG 416), Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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