| References: |
Doravirine is an investigational drug that is being studied for the treatment of HIV infection.
Doravirine belongs to a class (group) of HIV drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs).NNRTIs attach to and block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, NNRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.
In vitro, doravirine appears to work on certain HIV strains against which other FDA-approved NNRTIs, such as rilpivirine (brand name: Edurant) and efavirenz (brand name: Sustiva), may no longer work.(In vitro refers to studies done in test tubes or other laboratory equipment and not on animals or humans.) |
