UE2343(Xanamem)
产品编号: DC11783
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应用领域
UE2343 (UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2.
| Cas No.: |
1346013-80-6 |
| 名称: |
(5-(1H-pyrazol-4-yl)thiophen-3-yl)((1R,3r,5S)-3-hydroxy-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone |
| 别名: |
UE-2343;UE 2343;Xanamem |
| SMILES: |
C(C1C=C(C2=CNN=C2)SC=1)(N1[C@@]([H])2CC[C@@]1([H])C[C@](O)(C1=NC=CC=N1)C2)=O |
| 分子式: |
C19H19N5O2S |
| 分子量: |
381.454 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
UE2343 (UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2; displays a superior preclinical profile for further development, and shows potential for cognitive impairment in early Alzheimer's disease (AD). |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
