ML-240
产品编号: DC8576
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应用领域
ML240 是一种有效的 p97 抑制剂，抑制 p97 ATPase，IC50 值为 100 nM。
| Cas No.: |
1346527-98-7 |
| 名称: |
2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine |
| 别名: |
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| SMILES: |
COC1=CC=CC2=C1N=C(N=C2NCC3=CC=CC=C3)N4C5=CC=CC=C5N=C4N |
| 分子式: |
C23H20N6O |
| 分子量: |
396.44 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
ATP-competitive inhibitor of p97 ATPase (IC50 = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway. |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
