CNDAC

产品编号: DC9799 Featured
CNDAC
结构式
135598-68-4
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中国地区超过5000个高品质化合物库存
应用领域
CNDAC 是 sapacitabine 的有效代谢物,为一种核苷类似物。
Cas No.: 135598-68-4
名称: 1-(2-C-cyano-2-deoxy-β-D-arabino-pentofuranosyl)-cytosine
别名:
SMILES: C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)C#N
分子式: C11H14N4O3
分子量: 250.11
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: CNDAC is the active component of sapacitabine. Sapacitabine is an oral nucleoside analog prodrug that acts through a dual mechanism. The compound interferes with DNA synthesis by causing single-strand DNA breaks and induces arrest of the cell division cycle at G2 phase.Both sapacitabine and its major metabolite, CNDAC, have demonstrated potent anti-tumor activity in both blood and solid tumors in preclinical studies. In a liver metastatic mouse model, sapacitabine was shown to be superior to gemcitabine or 5-FU, two widely used nucleoside analogs, in delaying the onset and growth of liver metastasis.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC9799 CNDAC CNDAC 是 sapacitabine 的有效代谢物,为一种核苷类似物。