| Cas No.: | 1358099-18-9 |
| 名称: | 1-(4-benzylpiperidin-1-yl)-3-(3,5-dimethyl-1-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl)propan-1-one |
| 别名: | TRAF6-Ubc13 inhibitor C25-140 |
| SMILES: | C(N1CCC(CC2=CC=CC=C2)CC1)(=O)CCC1=C(C)N(C2=NN3C(C)=NN=C3C=C2)N=C1C |
| 分子式: | C26H31N7O |
| 分子量: | 457.582 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
| In Vivo: | |
| In Vitro: | |
| References: | C25-140 is a specific, first-in-class small molecule inhibitor of the TRAF6-Ubc13 interaction, binds TRAF6, inhibits TRAF6-Ubc13 interaction and TRAF6 activity; C25-140 effectively reduced TRAF6-mediated ubiquitin chain formation in vitro, impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells; does not effect other E3 ligases (MDM2, TRIM63, ITCH, E6AP and RNF4), also does inhibit E1/E2 reactions. |
| Kinase Assay: | |
| Cell Assay: | |
| Animal Administration: | |
| References: |
MSDS
| TITLE | DOWNLOAD |
| MSDS_658_DC10937_1358099-18-9 |
|
COA
| LOT NO. | DOWNLOAD |
|
|
