AMG-3969
产品编号: DC10101
Featured
我们的合作伙伴:
中国地区超过5000个高品质化合物库存
应用领域
AMG-3969是有效的葡萄糖激酶-葡糖激酶调节蛋白(GK-GKRP)相互作用的干扰物，IC50值为4 nM。
| Cas No.: |
1361224-53-4 |
| 名称: |
|
| 别名: |
AMG-3969; AMG 3969; AMG3969 |
| SMILES: |
OC(C(F)(F)F)(C1=CC=C(N2[C@@H](C#CC)CN(S(=O)(C3=CC=C(N)N=C3)=O)CC2)C=C1)C(F)(F)F |
| 分子式: |
C21H20F6N4O3S |
| 分子量: |
522.46 |
| 纯度: |
|
| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
|
| In Vivo: |
|
| In Vitro: |
|
| References: |
AMG-3969, a novel and stable small-molecule disruptor of glucokinase (GK) and glucokinase regulatory protein (GKRP) interaction by the optimization of initial screening hit and AMG-1694. AMG-3969 potently induced the dissociation of the GK-GKRP complex and promoted GK translocation both in-vitro and in-vivo. In rodent model of diabetes, AMG-3969 reduced blood glucose levels without affecting euglycemic animals. The study represents the first successful discovery of a small molecule that targets the GK-GKRP complex as a novel pathway for managing blood glucose levels with reduced hypoglycemic risk. |
| Kinase Assay: |
|
| Cell Assay: |
|
| Animal Administration: |
|
| References: |
|
MSDS
| TITLE |
DOWNLOAD |
| MSDS_87_DC10101_1361224-53-4 |
|
COA
| LOT NO. |
DOWNLOAD |
|
|
询盘
