AX-024 free base
产品编号: DC11802
我们的合作伙伴:
中国地区超过5000个高品质化合物库存
应用领域
AX-024 是一种口服可利用的，一流的 TCR-Nck 相互作用抑制剂，可选择性地抑制 TCR 触发的 T 细胞活化，IC50 值为 1 nM。AX-024 通过靶向 SH3 结构域调节细胞信号传导。AX-024 具有低毒、高效、高选择性的特点。AX-024 有效抑制白细胞介素-6 (IL-6)，肿瘤坏死因子-α (TNFα)，干扰素-γ (IFN-γ)，IL-10 和 IL-17A 的产生。
| Cas No.: |
1370544-73-2 |
| 名称: |
1-((4-(4-fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine |
| 别名: |
AX 024;AX024 |
| SMILES: |
N(CC1=C(C2=CC=C(F)C=C2)C2=C(OC1)C=CC(OC)=C2)1CCCC1 |
| 分子式: |
C21H22FNO2 |
| 分子量: |
339.41 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
A potent, orally available inhibitor of TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with IC50 of 1 nM; inhibits phosphorylation of ZAP70 at Tyr319 and of CD3ζ at Tyr142; inhibits TCR triggering-induced gene expression (1093 genes), including genes that are relevant for inflammatory T cell responses (cytokines IL-17A, IL-2, IL-6R and IL-18R1); attenuates the severity of skin inflammation in a psoriasis model as well as of lung inflammation in an asthma model. |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
