G-36

产品编号: DC10816 Featured
G-36
结构式
1392487-51-2
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中国地区超过5000个高品质化合物库存
应用领域
(3aS,4R,9bR)-4-(6-Bromo-1,3-benzodioxol-5-yl)-8-isopropyl-3a,4,5, 9b-tetrahydro-3H-cyclopenta[c]quinoline
Cas No.: 1392487-51-2
名称: (4S)-rel-4-(6-bromo-1,3-benzodioxol-5-yl)-3aR,4,5,9bS-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline
别名: G-36,G36,G 36
SMILES: CC(C1=CC2=C(N[C@H](C3=C(Br)C=C(OCO4)C4=C3)[C@@]5([H])[C@]2([H])C=CC5)C=C1)C
分子式: C22H22BrNO2
分子量: 412.3
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: G-36 is a cell-permeable non-steroidal antagonist of GPER, inhibiting activation by either 17β-estradiol or the GPER-selective agonist G-1(IC50 = 112 and 165 nM, respectively).It has no detectable binding activity to either ERα or ERβ.G-36 blocks the activation of PI3K or calcium mobilization triggered by estrogen through GPER and it suppresses ERK activation by estrogen or G-1 but not by EGF.3 G-36 can be used in combination with GPER-selective agonists, like G-1, to distinguish the roles of GPER from those of ERα and ERβ in complex biological systems.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC10816 G-36 (3aS,4R,9bR)-4-(6-Bromo-1,3-benzodioxol-5-yl)-8-isopropyl-3a,4,5, 9b-tetrahydro-3H-cyclopenta[c]quinoline
DC10814 G-15 G15 是一种高亲和力和选择性 G 蛋白偶联雌激素受体 (GPER/GPR30) 拮抗剂,Ki 值为 20 nM。