| Cas No.: | 14003-96-4 |
| 名称: | |
| 别名: | |
| SMILES: | O=CC1=C(O)C=CC2=C1OC(C=C2C)=O |
| 分子式: | C11H8O4 |
| 分子量: | 204.18 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
| In Vivo: | |
| In Vitro: | |
| References: | 4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM. IRE1 Rnase-selective inhibitor, used as a platform for developing new locally acting drugs.4μ8C blocks substrate(RIDD) access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation. IRE1 inhibition subsequently induces ER stress without measureable acute toxicity. 4μ8C, as an IRE1 inhibitor, blocks IL-4, IL-5, and IL-13 production from CD4+ T cells. |
| Kinase Assay: | |
| Cell Assay: | |
| Animal Administration: | |
| References: |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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