| References: |
Description of PF-543: PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective For SphK1 over the SphK2 iso Form. PF-543 was effective as a potent inhibitor of S1P Formation in whole blood, indicating that the SphK1 iso Form of sphingosine kinase is the major source of S1P in human blood. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful For dissecting specific roles of SphK1-driven S1P signalling. (source: Biochem J. 2012 May 15;444(1):79-88. doi: 10.1042/BJ20111929.)
For the detailed information about the solubility of PF-543 in water, the solubility of PF-543 in DMSO, the solubility of PF-543 in PBS buffer, the animal experiment（test） of PF-543,the in vivo,in vitro and clinical trial test of PF-543,the cell experiment（test） of PF-543,the IC50, EC50 and Affinity of PF-543, please contact DC Chemicals. |
