| Cas No.: | 1429054-28-3 |
| 名称: | 2-(4-((3r,5r,7r)-adamantan-1-yl)phenoxy)-1-(4-methylpiperazin-1-yl)ethan-1-one |
| 别名: | IDF 11774;IDF11774 |
| SMILES: | C(N1CCN(C)CC1)(=O)COC1=CC=C(C23C[C@]([H])4C[C@@H](C[C@@H](C4)C2)C3)C=C1 |
| 分子式: | C23H32N2O2 |
| 分子量: | 368.521 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
| In Vivo: | |
| In Vitro: | |
| References: | A potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells; suppresses the mRNA expression of HIF-1 target genes VEGF and EPO but not HIF-1α; inhibits the accumulation of HIF-1α in vitro and in vivo in colorectal carcinoma HCT116 cells; exhibits substantial anticancer efficacy in mouse models containing KRAS, PTEN, or VHL mutations. |
| Kinase Assay: | |
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| Animal Administration: | |
| References: |
MSDS
| TITLE | DOWNLOAD |
| MSDS_836_DC11782_1429054-28-3 |
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COA
| LOT NO. | DOWNLOAD |
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