CB-839(Telaglenastat)

产品编号: DC8042 Featured
CB-839(Telaglenastat)
结构式
1439399-58-2
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中国地区超过5000个高品质化合物库存
应用领域
Telaglenastat (CB-839) 是一种一流的,选择性的,可逆性的,口服活性的谷氨酰胺酶 1 (GLS1) 抑制剂。Telaglenastat 抑制 GLS1 剪接变异体 KGA 和 GAC,比 GLS2 具有更高的选择性。Telaglenastat 对小鼠类肾和脑中的内源性谷氨酰胺酶的 IC50 值分别为 23 nM 和 28 nM。Telaglenastat 还可诱导细胞自噬 (autophagy),并具有强大的抗肿瘤活性。
Cas No.: 1439399-58-2
名称: 2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol-2-yl)acetamide
别名: CB839 ,CB 839 ,CB-839
SMILES: C(NC1=NN=C(CCCCC2=NN=C(NC(=O)CC3=CC=CC(OC(F)(F)F)=C3)C=C2)S1)(=O)CC1=NC=CC=C1
分子式: C26H24F3N7O3S
分子量: 571.1
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: CB-839 is an investigational drug that works by inhibiting an enzyme involved in cancer metabolism called glutaminase. CB-839 has been shown to halt the growth of or kill cancer cells across a range of tumor types. The compound has demonstrated antitumor activity in several different tumor models in animals. In preclinical toxicology studies, CB-839 was well tolerated in animals at doses above those shown to inhibit tumor growth. CB-839 has also shown strong synergy with immunomodulatory agents and several kinase inhibitors that target growth factor pathways. For the detailed information of CB-839, the solubility of CB-839 in water, the solubility of CB-839 in DMSO, the solubility of CB-839 in PBS buffer, the animal experiment (test) of CB-839, the cell expriment (test) of CB-839, the in vivo, in vitro and clinical trial test of CB-839, the EC50, IC50,and affinity,of CB-839, For the detailed information of CB-839, the solubility of CB-839 in water, the solubility of CB-839 in DMSO, the solubility of CB-839 in PBS buffer, the animal experiment (test) of CB-839, the cell expriment (test) of CB-839, the in vivo, in vitro and clinical trial test of CB-839, the EC50, IC50,and affinity,of CB-839, Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC8042 CB-839(Telaglenastat) Telaglenastat (CB-839) 是一种一流的,选择性的,可逆性的,口服活性的谷氨酰胺酶 1 (GLS1) 抑制剂。Telaglenastat 抑制 GLS1 剪接变异体 KGA 和 GAC,比 GLS2 具有更高的选择性。Telaglenastat 对小鼠类肾和脑中的内源性谷氨酰胺酶的 IC50 值分别为 23 nM 和 28 nM。Telaglenastat 还可诱导细胞自噬 (autophagy),并具有强大的抗肿瘤活性。