Adavivint
产品编号: DC11886
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应用领域
Adavivint (SM04690; Lorecivivint) 是一种有效的，选择性的典型的 Wnt 信号通路抑制剂，在 SW480 细胞中，用高通量 TCF/LEF 报告基因实验，测得 EC50 值为 19.5 nM。
| Cas No.: |
1467093-03-3 |
| 名称: |
N-(5-{3-[7-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl}pyridin-3-yl)-3-methylbutanamide |
| 别名: |
SM-04690;SM 04690;SM04690 |
| SMILES: |
C(NC1=CC(C2C=CC3=C(C=2)C(C2NC4C(C5=CC=CC(F)=C5)=CN=CC=4N=2)=NN3)=CN=C1)(=O)CC(C)C |
| 分子式: |
C29H24FN7O |
| 分子量: |
505.55 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
Adavivint (SM-04690, SM 04690, SM04690) is a novel small molecule Wnt pathway inhibitor with EC50 of 3 nM in vitro; induces hMSC differentiation into mature, functional chondrocytes and decreases cartilage catabolic marker levels; significantly improves Osteoarthritis Research Society International (OARSI) histology scores and biomarkers in a rodent OA model. |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_843_DC11886_1467093-03-3 |
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COA
| LOT NO. |
DOWNLOAD |
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