CB-5083
产品编号: DC8840
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应用领域
CB-5083是有效，选择性和有口服活性的 p97 抑制剂，IC50 值为 11 nM。
| Cas No.: |
1542705-92-9 |
| 名称: |
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| 别名: |
CB 5083,CB5083 |
| SMILES: |
O=C(C1=CC=CC2=C1C=C(C)N2C3=NC(NCC4=CC=CC=C4)=C(COCC5)C5=N3)N |
| 分子式: |
C24H23N5O2 |
| 分子量: |
413.4 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration. CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer. |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_2531_DC8840_1542705-92-9 |
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COA
| LOT NO. |
DOWNLOAD |
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询盘
