AB423

产品编号: DC10797 Featured
AB423
结构式
1572510-80-5
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中国地区超过5000个高品质化合物库存
应用领域
AB-423 是一种 HBV 衣壳组装抑制剂,在细胞中,能够抑制 HBV 复制,EC50/EC90 值分别为 0.08-0.27 μM/0.33-1.32 μM。
Cas No.: 1572510-80-5
名称:
别名: AB423,AB-423,AB 423
SMILES: C1=C(S(=O)(=O)N[C@@H](C)CC)C=CC(F)=C1C(=O)NC1=CC(F)=C(F)C=C1
分子式: C17H17F3N2O3S
分子量: 386.09
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: AB-423 is a potent, highly seletive inhibitor of HBV replication through a block of pgRNA encapsidation. AB-423 in combination with EVT has shown synergistic antiviral activity in vitro in primary human hepatocytes. Furthermore, AB-423 alone and in combination with entecavir has shown potent in vivo activity in a hydrodynamic injection (HDI) mouse model of HBV.The HBV capsid inhibitor AB-423 exhibits a dual mode of inhibition:inhibited encapsidation of pgRNA during ongoing infection; inhibited cccDNA synthesis presumably via inhibition of the capsid uncoating step.In vitro AB-423 showed: pan-genotypic activity; potent activity against HBV in combination with Nucs, IFN, and RNAi agents;no significant activity against unrelated viruses.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC10797 AB423 AB-423 是一种 HBV 衣壳组装抑制剂,在细胞中,能够抑制 HBV 复制,EC50/EC90 值分别为 0.08-0.27 μM/0.33-1.32 μM。