CF-102(2-Cl-IB-MECA)
产品编号: DC10440
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应用领域
Namodenoson (CF-102) 是一个选择性的 A3 adenosine 受体的激动剂，选择性分别是A1，A2的2500到1400倍。
| Cas No.: |
163042-96-4 |
| 名称: |
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| 别名: |
CF102; CF-102; CF 102; Cl-IB-MECA; 2-Cl-IB-MECA |
| SMILES: |
O[C@H]1[C@H](N2C=NC3=C(NCC4=CC=CC(I)=C4)N=C(Cl)N=C23)O[C@H](C(NC)=O)[C@H]1O |
| 分子式: |
C18H18CliN6O4 |
| 分子量: |
544.73 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
2-Cl-IB-MECA is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively.
In vitro: In human ADF cells of astroglial lineage, 100 nM Cl-IB-MECA caused a marked reorganization of the cytoskeleton, with appearance of stress fibres and numerous cell protrusions. High concentrations of Cl-IB-MECA directly cause influx of Ca2+.
In vivo: Intravenous administration of 200 μg/kg 2-Cl-IB-MECA resulted in a short-lasting hypotension, which was accompanied by a 50–100-fold increase in plasma histamine concentrations. Administration of a second dose of 2-Cl-IB-MECA did not elicit any hemodynamic effects. |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_210_DC10440_163042-96-4 |
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COA
| LOT NO. |
DOWNLOAD |
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