M-3814(nedisertib)
产品编号: DC10749
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应用领域
Nedisertib (M3814) 是一个有效且有选择性的 DNA 依赖性蛋白激酶 (DNA-PK) 的抑制剂，IC50 值小于 3 nM。
| Cas No.: |
1637542-33-6 |
| 名称: |
(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol |
| 别名: |
MSC2490484A; MSC-2490484A; MSC 2490484A; M3814; M-3814; M 3814; nedisertib |
| SMILES: |
COC1=CC=C([C@@H](O)C2=CC(C3=C(C=CC(N4CCOCC4)=C5)C5=NC=N3)=C(F)C=C2Cl)N=N1 |
| 分子式: |
C24H21ClFN5O3 |
| 分子量: |
481.13 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
M-3814(nedisertib) is an orally available inhibitor of DNA-dependent protein kinase (DNA-PK), with potential antineoplastic and chemo/radiosensitizing activities. Upon oral administration, the DNA-PK inhibitor MSC2490484A binds to and inhibits the activity of DNA-PK. This inhibits the ability of tumor cells to repair damaged DNA, which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK. |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_495_DC10749_1637542-33-6 |
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COA
| LOT NO. |
DOWNLOAD |
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