SA4503 2HCl

产品编号: DC8227 Featured
SA4503 2HCl
结构式
165377-44-6
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中国地区超过5000个高品质化合物库存
应用领域
Cutamesine dihydrochloride (SA4503 dihydrochloride; AGY94806 dihydrochloride) 是一种有效的 Sigma 1 受体激动剂,在豚鼠脑膜中的 IC50 值为 17.4 nM。
Cas No.: 165377-44-6
名称: 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazinedihydrochloride
别名: SA 4503,SA-4503
SMILES: COC1=C(C=C(C=C1)CCN2CCN(CC2)CCCC3=CC=CC=C3)OC.Cl.Cl
分子式: C23H34Cl2N2O2
分子量: 441.43
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: in vitro: SA4503 showed little affinity for 36 other receptors, ion channels and second messenger systems. SA4503 significantly increased the KD value, but did not affect the Bmax value for specific (+)-[3H]pentazocine binding. SA4503 is a potent and selective agonist for the sigma 1 receptor subtype in the brain. At concentrations of 1-10μM, SA4503 reduced SOD1(G93A)-induced cell death in a concentration-dependent manner. in vivo: The intravenous administration of SA4503 (0.01-1.28 mg/kg) did not significantly alter the firing rate or pattern of spontaneously active DA neurons in either the SNC or VTA. A single injection of either 0.1 or 0.3 mg/kg i.p. of SA4503 did not alter the number of spontaneously active SNC and VTA DA neurons. In contrast, a single injection of 1 mg/kg i.p. of SA4503 produced a significant decrease and increase in the number of spontaneously active SNC and VTA DA neurons, respectively. SA4503 suppressed the progression of ALS in an SOD1(G93A) ALS mouse model. SA4503 did not affect the onset time of ALS. However, it significantly extended the survival time in the SOD1(G93A) mice compared with a vehicle-treated group. For the detailed information of SA4503 2HCl, the solubility of SA4503 2HCl in water, the solubility of SA4503 2HCl in DMSO, the solubility of SA4503 2HCl in PBS buffer, the animal experiment (test) of SA4503 2HCl, the cell expriment (test) of SA4503 2HCl, the in vivo, in vitro and clinical trial test of SA4503 2HCl, the EC50, IC50,and affinity,of SA4503 2HCl, For the detailed information of SA4503 2HCl, the solubility of SA4503 2HCl in water, the solubility of SA4503 2HCl in DMSO, the solubility of SA4503 2HCl in PBS buffer, the animal experiment (test) of SA4503 2HCl, the cell expriment (test) of SA4503 2HCl, the in vivo, in vitro and clinical trial test of SA4503 2HCl, the EC50, IC50,and affinity,of SA4503 2HCl, Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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