Anacardic Acid

产品编号: DC8322 Featured
Anacardic Acid
结构式
16611-84-0
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中国地区超过5000个高品质化合物库存
应用领域
Anacardic Acid 是从从腰果壳中提取液中分离到的酸类物质,为 histone acetyltransferases 抑制剂,对 p300 和 PCAF 的 IC50 值分别为 ∼8.5 μM 和 ∼5 μM。
Cas No.: 16611-84-0
名称: 2-​hydroxy-​6-​pentadecyl-​benzoic acid
别名:
SMILES: CCCCCCCCCCCCCCCC1=C(C(=CC=C1)O)C(=O)O
分子式: C22H36O3
分子量: 348.52
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Anacardic Acid is a pentadecane aliphatic chain containing hydroxylcarboxylic acid. The acid is an effective inhibitor of the activities of p300, p300/CBP associated factor histone acetyltransferase, prostaglandin synthase (PTGS2 or Cox-2), tyrosinase, urease-α and -β, lipoxygenase (LO), and xanthine oxidase. Additionally, it has been shown to potently inhibit HAT-dependent transcription and SUMOylation, as well as decrease expression of NF-κB regulated gene products at high concentrations. Research suggests that anacardic acid is a potent activator of ARK-1 (Aurora kinase A) mediated phosphorylation of histone H3 while leaving ARK-2 unaffected in vitro. Anacardic acid has demonstrated bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA). For the detailed information of Anacardic Acid, the solubility of Anacardic Acid in water, the solubility of Anacardic Acid in DMSO, the solubility of Anacardic Acid in PBS buffer, the animal experiment (test) of Anacardic Acid, the cell expriment (test) of Anacardic Acid, the in vivo, in vitro and clinical trial test of Anacardic Acid, the EC50, IC50,and affinity,of Anacardic Acid, For the detailed information of Anacardic Acid, the solubility of Anacardic Acid in water, the solubility of Anacardic Acid in DMSO, the solubility of Anacardic Acid in PBS buffer, the animal experiment (test) of Anacardic Acid, the cell expriment (test) of Anacardic Acid, the in vivo, in vitro and clinical trial test of Anacardic Acid, the EC50, IC50,and affinity,of Anacardic Acid, Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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