| Cas No.: | 1672665-49-4 |
| 名称: | |
| 别名: | PT 2385,PT-2385 |
| SMILES: | CS(=O)(=O)C1=C2[C@@H](C(CC2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)(F)F)O |
| 分子式: | C17H12F3NO4S |
| 分子量: | 383.34 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
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| In Vitro: | |
| References: | PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor PT2385 allosterically binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. |
| Kinase Assay: | |
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| Animal Administration: | |
| References: |
MSDS
| TITLE | DOWNLOAD |
| MSDS_232_DC10464_1672665-49-4 |
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COA
| LOT NO. | DOWNLOAD |
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