PD-1/PD-L1 inhibitor 2(BMS-202)

产品编号: DC8381 Featured
PD-1/PD-L1 inhibitor 2(BMS-202)
结构式
1675203-84-5
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中国地区超过5000个高品质化合物库存
应用领域
BMS-202 是一种有效的非肽类 PD-1/PD-L 复合物抑制剂,其 IC50 为 18 nM,KD 为 8 μM。BMS-202 与 PD-L1 直接结合并阻断人类 PD-1/PD-L 的相互作用。BMS-202 具有抗肿瘤活性。
Cas No.: 1675203-84-5
名称: N-[2-[[[2-methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]-acetamide
别名: PD-L1 inhibitor 2,PD-1 inhibitor 2,PD1 inhibitor 2,PD 1 inhibitor 2,BMS 202,BMS202
SMILES: C(NCCNCC1=CC=C(OCC2C=CC=C(C3=CC=CC=C3)C=2C)N=C1OC)(=O)C
分子式: C25H29N3O3
分子量: 419.52
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: The inhibition of the interaction of PD-Ll with PD-1 is thus a viable and promising therapeutic target for the treatment of cancer and/or chronic infections. The invention in this patent application presents compounds with activities as inhibitors of the PD-1/PD-Ll protein/protein interactions.For the detailed information of PD-1/PD-L1 inhibitor 2, the solubility of PD-1/PD-L1 inhibitor 2 in water, the solubility of PD-1/PD-L1 inhibitor 2 in DMSO, the solubility of PD-1/PD-L1 inhibitor 2 in PBS buffer, the animal experiment (test) of PD-1/PD-L1 inhibitor 2, the cell expriment (test) of PD-1/PD-L1 inhibitor 2, the in vivo, in vitro and clinical trial test of PD-1/PD-L1 inhibitor 2, the EC50, IC50,and affinity,of PD-1/PD-L1 inhibitor 2, For the detailed information of PD-1/PD-L1 inhibitor 2, the solubility of PD-1/PD-L1 inhibitor 2 in water, the solubility of PD-1/PD-L1 inhibitor 2 in DMSO, the solubility of PD-1/PD-L1 inhibitor 2 in PBS buffer, the animal experiment (test) of PD-1/PD-L1 inhibitor 2, the cell expriment (test) of PD-1/PD-L1 inhibitor 2, the in vivo, in vitro and clinical trial test of PD-1/PD-L1 inhibitor 2, the EC50, IC50,and affinity,of PD-1/PD-L1 inhibitor 2, Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC12058 BMS-1166 BMS-1166 是 PD-1/PD-L1 相互作用的有效抑制剂,其 IC50 值为 1.4 nM。BMS-1166 可拮抗 PD-1/PD-L1 免疫检查点对 T 细胞活化的抑制作用。
DC9280 PD-1/PD-L1 inhibitor 1(C1) BMS-1 是 PD-1/PD-L1 蛋白质/蛋白质相互作用的抑制剂,IC50 为 6 到 100 nM。
DC8381 PD-1/PD-L1 inhibitor 2(BMS-202) BMS-202 是一种有效的非肽类 PD-1/PD-L 复合物抑制剂,其 IC50 为 18 nM,KD 为 8 μM。BMS-202 与 PD-L1 直接结合并阻断人类 PD-1/PD-L 的相互作用。BMS-202 具有抗肿瘤活性。
DC10330 CA-170 (AUPM-170)|PDL1 inhibitor PD-1-IN-1 是 PD-1 的抑制剂, 来自专利 WO2015033299A1,化合物实例 4。PD-1-IN-1 可作为免疫调节剂。