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Dibutyryl-cAMP (Bucladesine)

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Dibutyryl-cAMP (Bucladesine)
结构式
16980-89-5
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中国地区超过5000个高品质化合物库存
应用领域
Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) 是一种稳定的环 AMP (cAMP) 类似物，也是一种选择性的 PKA 活化剂，可提高细胞内 cAMP 的水平。Bucladesine sodium salt 也是一种磷酸二酯 (PDE) 抑制剂。Bucladesine sodium salt 具有抗炎活性，可用于伤口愈合不良。
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 16980-89-5
名称: N-(1-oxobutyl)-cyclic 3',5'-(hydrogen phosphate) 2'-butanoate-adenosine,sodium salt (1?)
别名:
SMILES: O.[Na+].CCCC(NC1N=CN=C2N([C@@H]3O[C@@H]4COP(O[C@@H]4C3OC(CCC)=O)(=O)[O-])C=NC=12)=O
分子式: C18H23N5NaO8P
分子量: 491.37
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Dibutyryl-cAMP inhibits neuronal glucose uptake via PKA activation. In cultured rat hepatocytes, Dibutyryl-cAMP inhibits inducible nitric oxide synthase expression and NF-kappaB-binding activity. Dibutyryl-cAMP also suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation. In a mouse model, bucladesine (600 nM/mouse, i.p.) reverses zinc chloride- and lead acetate-induced avoidance memory retention impairments. For the detailed information of Dibutyryl-cAMP (Bucladesine), the solubility of Dibutyryl-cAMP (Bucladesine) in water, the solubility of Dibutyryl-cAMP (Bucladesine) in DMSO, the solubility of Dibutyryl-cAMP (Bucladesine) in PBS buffer, the animal experiment (test) of Dibutyryl-cAMP (Bucladesine), the cell expriment (test) of Dibutyryl-cAMP (Bucladesine), the in vivo, in vitro and clinical trial test of Dibutyryl-cAMP (Bucladesine), the EC50, IC50,and affinity,of Dibutyryl-cAMP (Bucladesine), For the detailed information of Dibutyryl-cAMP (Bucladesine), the solubility of Dibutyryl-cAMP (Bucladesine) in water, the solubility of Dibutyryl-cAMP (Bucladesine) in DMSO, the solubility of Dibutyryl-cAMP (Bucladesine) in PBS buffer, the animal experiment (test) of Dibutyryl-cAMP (Bucladesine), the cell expriment (test) of Dibutyryl-cAMP (Bucladesine), the in vivo, in vitro and clinical trial test of Dibutyryl-cAMP (Bucladesine), the EC50, IC50,and affinity,of Dibutyryl-cAMP (Bucladesine), Please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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